1
: a soiling or disfiguring mark : spot
2
: a mark of reproach : moral flaw
3
: a usually nitrocellulose or nylon sheet that contains spots of immobilized macromolecules (as of DNA, RNA, or protein) or their fragments and is used to identify specific components of the spots by applying a molecular probe (such as a complementary nucleic acid or a radiolabeled antibody) compare southern blot, western blot
blotted; blotting
1
: to spot, stain, or spatter with a discoloring substance
2
3
a
: to dry (something, such as writing) with an absorbing agent
hastily blotted her letter
b
: to remove with absorbing material
blotting up spilled water
1
: a lone backgammon man exposed to capture
2
archaic
: a weak or exposed point
Cite this Entry
“Blot.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/blot. Accessed 14 Aug. 2026.
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