plural ceramides
: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids
The enzyme controls production of a cellular substance, ceramide, which triggers the natural process of egg cell death.L. Stivitz
Moisturizers containing ceramides (natural lipids that are similar in structure to those in the skin's own moisture barrier) … are also worthwhile splurges for women with dry or problem skin, according to independent tester Grove.Constance Cardozo

Examples of ceramide in a Sentence

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Oils, proteins, humectants, ceramides, antioxidants—all these buzzwords actually mean something. Anya Meyerowitz, Glamour, 2 Aug. 2026 The Manuka Essence has a 20% concentration of this incredible honey, along with hyaluronic acid, resveratrol, and a ceramide complex to hydrate, smooth texture, boost clarity, and increase cellular turnover. Audrey Noble, Vogue, 27 July 2026 Human skin is composed primarily of ceramides, fatty acids and cholesterol, which are not classified as saturated. Jenna Belhumeur, Los Angeles Times, 27 July 2026 The creamy formula is packed with rose extracts and rose oil to condition, plus hyaluronic acid to draw in moisture and ceramides to reinforce the lip barrier, leaving your lips softer and smoother with every swipe. Christa Joanna Lee, Allure, 26 July 2026 See All Example Sentences for ceramide

Word History

Etymology

cerebroside + amide

First Known Use

1958, in the meaning defined above

Time Traveler
The first known use of ceramide was in 1958

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Cite this Entry

“Ceramide.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/ceramide. Accessed 5 Aug. 2026.

Medical Definition

: any of a group of amido sphingolipids formed by linking a fatty acid to sphingosine and found widely in small amounts in plant and animal tissue

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