smallpox

noun

small·​pox ˈsmȯl-ˌpäks How to pronounce smallpox (audio)
: an acute contagious febrile disease of humans that is caused by a poxvirus (Orthopoxvirus variola), is characterized by a skin eruption with pustules, sloughing, and scar formation, and has been eradicated globally by widespread vaccination

called also variola

Examples of smallpox in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
While smallpox is no longer a daily concern, the latest DNA discoveries can help public health officials, biologists, and epidemiologists prepare for and fight future disease outbreaks. — Andrew Paul, Popular Science, 30 July 2026 The now extinct lineage branched off after medieval European strains but before those that gave rise to modern smallpox. — Sam MacDonald, Scientific American, 30 July 2026 As Jacobsen describes it, Al Qaeda buys smallpox from Russia and releases it in three American cities. — Gideon Lewis-Kraus, New Yorker, 25 July 2026 The introduction of vaccines dramatically reduced certain diseases, including smallpox, polio, diphtheria, measles and whooping cough. — Melissa Rudy, FOXNews.com, 3 July 2026 See All Example Sentences for smallpox

Word History

First Known Use

circa 1562, in the meaning defined above

Time Traveler
The first known use of smallpox was circa 1562

Rhymes for smallpox

See All Rhymes for smallpox

Browse Nearby Words

small potatoes
smallpox
smallpox plant
See all Nearby Words

Cite this Entry

“Smallpox.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/smallpox. Accessed 5 Aug. 2026.

Copy Citation

Kids Definition

smallpox

noun
small·​pox ˈsmȯl-ˌpäks How to pronounce smallpox (audio)
: a sometimes deadly disease that is caused by a virus, is characterized by fever and a skin rash, and is believed to have been wiped out worldwide as a result of vaccination

Medical Definition

smallpox

noun
small·​pox ˈsmȯl-ˌpäks How to pronounce smallpox (audio)
: an acute contagious febrile disease of humans that is caused by a poxvirus (Orthopoxvirus variola), is characterized by skin eruption with pustules, sloughing, and scar formation, and has been eradicated globally by widespread vaccination

called also variola

see variola major, variola minor

More from Merriam-Webster on smallpox

Nglish: Translation of smallpox for Spanish Speakers

Britannica.com: Encyclopedia article about smallpox

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

Popular in Grammar & Usage

See More

7 Pairs of Commonly Confused Words

Merriam-Webster’s Great Big List of Words You Love to Hate

Is it 'nerve-racking' or 'nerve-wracking'?

'Sneaked' or 'Snuck': Which is correct?

Why does English have so many silent letters?
See More

Popular in Wordplay

See More

The Longest Long Words List

It's a Scorcher! Words for the Summer Heat

14 Phobias You Probably Haven't Heard Of

How long is a jiffy?

Even More Bird Names that Sound Like Insults (and Sometimes Are)
See More

Popular

See More

7 Pairs of Commonly Confused Words

The Longest Long Words List

It's a Scorcher! Words for the Summer Heat
See More

Games & Quizzes

See All
Play Quordle: Guess all four words in a limited number of tries. Each of your guesses must be a real 5-letter word.
Quordle Can you solve 4 words at once?
Play Blossom: Solve today's spelling word game by finding as many words as you can using just 7 letters. Longer words score more points.
Blossom Pick the best words!
Play Missing Letter: a crossword with a twist. Each of the 25 puzzle words start with a different letter of the alphabet. Which letter is missing?
The Missing Letter A daily crossword with a twist
asap street sign
Figure Out These Acronyms ASAP You don't have to be a NASA engineer to get these...
See All