FIRST-LINE Synonyms: 24 Similar and Opposite Words

first-line

adjective

ˈfərst-ˈlīn

Definition of first-line

as in selected

singled out from a number or group as more to one's liking surgery is usually not considered a first-line treatment for this type of cancer

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Recent Examples of first-line Zidesamtinib is also being explored as a first-line treatment. — Meghana Keshavan, STAT, 23 July 2026 Cognitive behavioral therapy for insomnia, known as CBT-I, is considered the first-line treatment for chronic insomnia. — Hanna Wickes, Fort Worth Star-Telegram, 17 July 2026 For instance, if a patient with obesity is diagnosed with hypogonadism and no other condition explains the low testosterone levels (such as a pituitary tumor), the first-line treatment is weight loss. — Beth Mole, ArsTechnica, 17 July 2026 Today, the first-line therapy for a painful knee with degenerative tears is physical therapy and, for some people, weight loss. — Dr. Elisabeth Rosenthal, CBS News, 13 July 2026 See All Example Sentences for first-line

Recent Examples of Synonyms for first-line

Adjective

Some cool features include a kill switch that automatically disconnects you from the internet if the VPN connection fails, as well as split tunneling that allows selected apps to use the VPN connection while others transmit data in clear text.

— K. Thor Jensen, PC Magazine, 25 June 2026
These pre-selected fighter pilots and their families moved into their apartments during the summer of 1960 after residing at the Frunze Central Airfield in Moscow.

— Jeff Spry, Space.com, 27 May 2026

Definition of selected

Adjective

The Kubasik First Impact Program helps a select cohort of Maryland student-athletes each academic year prepare for life beyond their sport.

— Dan Mangan, CNBC, 17 Aug. 2026
To pull this off, Uber is working with the drone delivery provider Zipline, a company in South San Francisco that first focused on the African market before expanding in the US to deliver food and Walmart orders in select areas.

— Michael Kan, PC Magazine, 17 Aug. 2026

Definition of select

Adjective

Acts of Congress, however, are not Trump’s only tool, or necessarily his preferred one.

— Amy Davidson Sorkin, New Yorker, 16 Aug. 2026
James Bord, the professional poker player and owner of Scottish club Dunfermline Athletic, had initially been named the preferred bidder by administrators on Christmas Eve, only to withdraw from the process in late February.

— Philip Buckingham, New York Times, 14 Aug. 2026

Definition of preferred

Adjective

This dynamic that has produced a glut of companies in favored sectors like green technology, electric vehicles, and semiconductors, chasing far more customers than the market, domestic or global, can support.

— Nicholas Gordon, Fortune, 29 July 2026
Listenupshance was the surprise winner of Saturday’s Grade I Bing Crosby Stakes in a race marred by a right front leg injury to the favored Cornucopian.

— Bill Center, San Diego Union-Tribune, 26 July 2026

Definition of favored

Browse Nearby Words

first lady

first-line

firstly

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“First-line.” Merriam-Webster.com Thesaurus, Merriam-Webster, https://www.merriam-webster.com/thesaurus/first-line. Accessed 22 Aug. 2026.

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Synonyms of first-line

adjective

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